A different way to treat high blood pressure
Until now, the only way to treat high blood pressure was through diet, exercise, and medications. Today, there is an innovative approach that goes beyond lifestyle changes and medications to help manage high blood pressure more effectively.1,2
Answer a few questions to see if this procedure may be right for you.
What is the Symplicity™ blood pressure procedure?
The Symplicity™ procedure is a minimally invasive renal denervation procedure that works alongside lifestyle changes and medications to help control blood pressure more effectively.1,2
The kidney connection
In some people, nerves near the kidneys become overactive and make it harder to keep blood pressure in a healthy range.3 The Symplicity™ procedure works to calm the overactive nerves near the kidneys that may be contributing to your high blood pressure.4
Around-the-clock effectiveness
The effects of the Symplicity™ procedure keep working 24 hours a day, and while it may not reduce the number of pills you take today, it could help reduce your blood pressure without adding another pill to your daily regimen.1,2
Individual results after the Symplicity™ procedure will vary. Side effects may include headache, back pain, and access site issues like bruising or hematoma. After the procedure, your blood pressure will be monitored by your healthcare team, and medications may need to be adjusted over time.
Is the Symplicity™ procedure right for you?
The Symplicity™ procedure may be a good option if:
- You've tried lifestyle changes and medications, but your blood pressure is still high.
- You're interested in lowering your blood pressure without adding another daily pill.1,2
- You're looking for long-term results without the same side effects as another medication.†,5,6
Results vary and you’ll need to talk to a doctor to see if the Symplicity™ procedure is right for you. Answer a few questions to see if you meet the criteria for call center support. If so, we’ll put you in touch with one of our Education Support Specialists who can help answer your questions and find physicians near you who can perform the procedure.
What to expect
At the hospital, the doctor makes a small incision to insert a thin tube (called a catheter) into the artery leading to the kidney. Low-level energy is delivered through the catheter to calm overactive nerves near the kidney. The catheter is then removed, leaving nothing behind.
How long does the procedure take?
Hospitals vary, but a typical procedure takes about an hour not including the time it takes to prepare for the procedure or to recover afterwards.2
What are the risks?
The most frequently reported side effects include headache and back pain. Some patients experience bruising or a firm area under the skin (known as hematoma) where the catheter is inserted into the body. In very rare instances, blood vessel injury or narrowing may occur.
Will it affect my kidneys?
Every patient is different. However, clinical trial information through three years after the procedure has shown no impact on kidney function.7
High blood pressure raises your risk of8,9:
Stroke
Heart attack & failure
Kidney failure
How high is too high?
U.S. guidelines from the American Heart Association define high blood pressure as
any value greater than 130/80 mmHg.8
How is blood pressure measured?
1
2
Five main blood pressure ranges
Hear from real patients
Meet Danny
"Since getting this procedure, I feel like a free spirit again."
Danny, an avid adventurer, regained his high-energy lifestyle after the Symplicity™ procedure successfully alleviated the debilitating symptoms and limitations caused by his high blood pressure.
Meet Lisa
"This procedure brought me my life back."
High blood pressure made it hard for Lisa to fully enjoy traveling. After the Symplicity™ procedure, she felt more comfortable getting back to the things she loves without the constant worry.
Take the next step to see if the Symplicity™ procedure
may be right for you.
You’ll need to talk to a doctor to see if the Symplicity™ procedure is right for you. Answer a few questions to see if you meet the criteria for call center support provided by Medtronic.
† Long-term data available through three years.
1. Kandzari DE, Townsend RR, Kario K, et al. Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications. J Am Coll Cardiol. November 7, 2023;82(19):1809–1823.
2. Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomized, sham-controlled trial. Lancet.
May 2, 2020;395(10234):1444–1451.
3. Sata Y, Head GA, Denton K, May CN, Schlaich MP. Role of the Sympathetic Nervous System and Its Modulation in Renal Hypertension. Front Med (Lausanne). March 29, 2018;5:82.
4. Coates P, Tunev S, Trudel J, Hettrick DA. Time, Temperature, Power, and Impedance Considerations for Radiofrequency Catheter Renal Denervation. Cardiovasc Revasc Med. September 2022;42:171–177.
5. Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. April 9, 2022;399(10333):1401–1410.
6. Mahfoud F, Mancia G, Schmieder R, et al. Blood pressure and MACE reductions after renal denervation: 3-year Global Symplicity Registry results. Presented at: PCR e-Course 2022.
7. Schlaich M, et al. Long-term safety and efficacy of renal denervation with the Symplicity Spyral catheter in the Global SYMPLICITY Registry. Presented at: American Society of Nephrology Kidney Week, San Diego, CA.
November 4–7, 2021.
8. Jones DW, Ferdinand KC, Taler SJ, et al. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. November 4, 2025;86(18):1567–1678.
9. High blood pressure dangers: Hypertension’s effects on your body. Mayo Clinic. Available at: https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/high-blood-pressure/art-20045868. Accessed
August 18, 2026.
